منابع مشابه
Flux-P: Automating Metabolic Flux Analysis
Quantitative knowledge of intracellular fluxes in metabolic networks is invaluable for inferring metabolic system behavior and the design principles of biological systems. However, intracellular reaction rates can not often be calculated directly but have to be estimated; for instance, via 13C-based metabolic flux analysis, a model-based interpretation of stable carbon isotope patterns in inter...
متن کاملThermodynamics-based metabolic flux analysis.
A new form of metabolic flux analysis (MFA) called thermodynamics-based metabolic flux analysis (TMFA) is introduced with the capability of generating thermodynamically feasible flux and metabolite activity profiles on a genome scale. TMFA involves the use of a set of linear thermodynamic constraints in addition to the mass balance constraints typically used in MFA. TMFA produces flux distribut...
متن کاملFrom elementary flux modes to elementary flux vectors: Metabolic pathway analysis with arbitrary linear flux constraints
Elementary flux modes (EFMs) emerged as a formal concept to describe metabolic pathways and have become an established tool for constraint-based modeling and metabolic network analysis. EFMs are characteristic (support-minimal) vectors of the flux cone that contains all feasible steady-state flux vectors of a given metabolic network. EFMs account for (homogeneous) linear constraints arising fro...
متن کاملMetabolic flux interval analysis of CHO cells
Based on a detailed metabolic network of CHO-320 cells built using available information gathered from published reports, the flux distribution can be evaluated using tools of positive linear algebra (in particular, the algorithm METATOOL devised in T. Pfeiffer and Schuster (1999); S. Schuster (1999)), and to study the influence of the interconnection level of the network as well as the availab...
متن کاملAlgorithms for 13C metabolic flux analysis
The metabolism of an organism consists of a network of biochemical reactions that transform small molecules, or metabolites, into others in order to produce energy and building blocks for essential macromolecules. The goal of metabolic flux analysis is to uncover the rates, or the fluxes, of those biochemical reactions. In a steady state, the sum of the fluxes that produce an internal metabolit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Metabolites
سال: 2012
ISSN: 2218-1989
DOI: 10.3390/metabo2040872